Press releases

A close collaboration between scientific institutes and companies in the Friuli Venezia Giulia Region has produced promising results in the treatment of difficult wounds. A new advanced therapy for the effective resolution of difficult wounds has been published in the Nature group journal npj Regenerative Medicine. The study has shown how certain fat cells, named Stromal Vascular Fraction or SVF, are able to promote the formation of new blood vessels at the wound level, with important acceleration of healing time. Difficult wounds are extremely painful skin lesions that do not heal, and in fact worsen over time. This is caused by the coexistence of underlying chronic diseases, primarily diabetes and peripheral arterial disease, which do not allow adequate vascularization of the wound, which is necessary to ensure sufficient oxygen and nutrient supply, and thus healing. This is a common condition in people over 60, at least as common as heart failure, with major limitations in daily activities. The economic implications are important. About 3 percent of the global health budget is spent on the care of difficult wounds, which require specialized and expensive therapies: in Italy, more than 3 billion euros per year. Added to this is the reduction in the patient’s ability to work and the sometimes constant need for health care. This research, led by Serena Zacchigna, head of the Cardiovascular Biology Laboratory at the ICGEB and professor of Molecular Biology at the University of Trieste, was made possible by the PREFER project-Development of a Biocompatible PRoduct for the tErapy of Difficult FERites, funded by the 2014-2020 European Regional Development Fund Operational Program of Friuli-Venezia Giulia. In addition to ICGEB and UniTS, two regional companies, Zeta Research and Vivabiocell, led the project. “Currently available therapies are based on the application of skin substitutes to promote wound healing,” Zacchigna explains, “However, their effectiveness is limited by the inadequate vascularization that usually underlies this disease. How does this new therapy work? We took cells derived from the patients’ adipose tissue and applied them to the wound bed. After a few days, we observed the formation of a new vascular network, functional and connected with the pre-existing vessels.” “Restoring adequate blood supply to the wound is critical to support healing of the skin lesion,” continues Giovanni Papa, UniTS professor and Director of the Plastic Surgery Unit of the Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), which provided the cells and enabled validation of the efficacy. Collaboration between academia and business enabled this first milestone toward better care and quality of life for people with difficult wounds. Crucial to this journey was the participation of VivaBioCell, a leading manufacturer of bioreactors for cell therapies, which brought its industrial expertise and ability to transform research results into implementable solutions in a clinical reality. “The joint work between us academic researchers, hospital clinicians and the industrial research and development department was essential to define concrete goals that were compatible with the needs of the industrial scaling-up process,” says Roman Vuerich, first author of the paper and a doctoral student at UniTS and ICGEB. “This project was an example of how the synergy between academia and business can lead to concrete solutions to public health challenges.” “We are confident that this collaboration can continue in the future to bring an advanced therapy product to patients and serve as a beacon to promote other collaborative projects between research centers, hospitals and industry. Only through funding that supports the synergy between these entities will we be able to ensure that research results reach patients and that this can also happen in Italy,” Zacchigna and Papa concluded in unison. Link to the paper.

Trieste, 20 December 2022 – The research programme REFIBER, developed by Area Science Park and Innovando srl landed in Paris, as part of efforts to establish a national recycling chain for fibreglass boat hulls. The meeting took place at the recent Paris Boat Show, one of the most important events in the sector, seeing some 150,000 visitors and 650 exhibitors in attendance. “We met with representatives of the ‘Association pour la Plaisance Eco-Responsable (APER)’, the French consortium for collecting and dismantling pleasure boats and watercrafts, which today represents European best practice in the sector,” said Marcello Guaiana,president of the Temporary Association of Scope implementing the REFIBER programme. Our goal is to find the convergence between our research initiative and APER’s operations, to jointly evaluate innovative technologies for recycling materials from dismantling, and solutions for replacing critical materials to improve the sustainability of these vessels.” How to decommission and manage the disposal of end-of-life pleasure crafts is a major environmental, and socio-economic, issue. To date, there is still no structured collection model in Italy to correctly manage 10-24 m boats at the end of their life. So much so that, over the last ten years, only a very small percentage of the approximately 10,000 vessels removed from the official registers have been properly managed. The aim of REFIBER is to create a hub to concentrate and exploit the flows of materials left after a boat has been decommissioned. One of these materials is fibreglass, a multi-layered material made up of plastic and glass, which accounts for the largest proportion at 60% by weight and is the most difficult to process. One management model being analysed as part of the programme is the Extended Producer Responsibility (EPR) model, already well established in other fields. This model involves both the manufacturers and distributors from within the sector. “We want to contribute, in a coordinated way, to a harmonised development of European sector standards,” said Ivana Lazarevic, deputy director general of APER. “By working together, it will be easier to establish and share communication and awareness-raising activities with national and international stakeholders.” At this stage, the focus of the REFIBER programme is pleasure boats, but the system may be opened up to include vessels under 10 metres in the future. Francesco Di Pierro and Cveta Majtanovic of Innovando both hope that, “better mutual communication can speed up implementation of the REFIBER programme, building on APER’s many years of experience with private operators and public institutions, and sharing more good operating practices”. “In the medium term,” concluded Matilde Cecchi of Area Science Park, “we will be able to assess the optimum conditions for promoting and implementing collaborative initiatives and research projects aimed at experimenting with new technologies, to make the nautical sector more sustainable”.

The Mediterranean region warms 20% faster than other regions in the world and local authorities are at the forefront of the actions for adapting to and mitigating the multiple impacts of climate change. To this end the Urban Transports Community*, an Interreg MED Programme initiative, promotes sustainable urban mobility planning in the Euro-Mediterranean region as an effective tool to reduce carbon emissions and improve the quality of life of the population and the environment. The Community has gathered together almost 200 organisations (public authorities, associations, mobility planners, universities and international organisations, amongst others) from 12 Euro-Mediterranean countries. In support of local authorities it has elaborated and published a selection of tools and solutions with the highest replicability potential. As part of the project, the Area Science Park experts have developed several reports which constitute reference guides and a scientific basis for policy makers and urban planners to develop the planning of mobility and related infrastructures. Urban mobility Adaptation to Climate Change is the topic of the latest policy brief presented on December 14th 2022 during the online event “Mediterranean cities and climate change: making the urban transport sector more resilient and less impactful”. The policy brief describes the main impacts of climate change on urban mobility, with the aim of raising awareness among policy makers, suggesting possible solutions to minimize its effects and make the mobility system more resilient to climate change. Transport infrastructures will be exposed, in the next decades, to an increasing number of new challenges from climate impacts. Panning today for the construction of new and the management of existing infrastructures will require the consideration of new environmental, climatic and socio-economic parameters and conditions with respect to those used in the past. During the project Area Science Park drafted two other technical reports. The first one focused on the analysis of technological trends relating to electric vehicle charging infrastructure, and the second one on the spread of automated vehicles in the cities. The reports are available here: https://urban-transports.interreg-med.eu/policy-briefs/ *The Urban Transports Community is featured by a project led by MedCities (Barcelona, Spain), in partnership with UNIMED Mediterranean Universities Union (Rome, Italy), Area Science Park (Trieste, Italy), CODATU (Lyon, France), CIVINET CY-EL (Cyprus-Greece), POLIS, Cities and Regions for transport innovation (Brussels, Belgium), and Durres Municipality (Durres, Albania).

Alzheimer’s disease is not the same for men and women: certain molecular mechanisms in fact differ between the two sexes, particularly in terms of metabolism of an amino acid that has recently been proposed as an early marker of this disease and which would therefore not be equally reliable for men and women. These are the findings of an Italian study published in “Cell Reports” in September and led by the University of Milan, with collaboration of the Insubria University, University of Milano-Bicocca, Rome’s Tor Vergata University and the Area Science Park Genomics and Epigenomics Laboratory (LAGE). The research paves the way for distinct and personalised treatment based on gender. Researchers analysed post-mortem samples from the brains of men and women with normal ageing and from patients of Alzheimer’s disease. Area Science Park’s contribution, explains Danilo Licastro, Head of LAGE, was focused on genomic and epigenomic analysis. The greatest challenge was to define and implement an analysis protocol that was compatible with the RNA tissue samples sent by the University of Tor Vergata and previously provided by biobanks, because this post-mortem tissue did not present the same quality as fresh tissue. Analysis highlighted marked differences in terms of the metabolic pathways altered. Two examples are insulin response and metabolism of the amino acid serine (which generates an important regulator of cerebral function, D-Serine). This is of particular interest because D-Serine modulates neurotransmission and also because its levels in the blood have been proposed as an early marker of this disease. “These results demonstrate how Alzheimer’s changes and, in certain aspects, inverts some features in the two sexes”, commented Elisa Maffioli, from the University of Milan, “highlighting how different mechanisms are active or not based on gender and opening the possibility of treatment with innovative approaches that differ for men and women”.   Read the whole article: Insulin and serine metabolism as sex-specific hallmarks of Alzheimer’s disease in the human hippocampus

From 16th to 20th May, Danish artist Sissel Marie Tonn has been guest at Area Science Park’s labs to work on her art residency project “The Sentinel Immune Self”. She is the winner of the “Preserving co-evolution” challenge organised as part of the European S+T+ARTS programme. S+T+ARTS (Science + Technology + Arts) is a European Commission initiative launched under the Horizon 2020 programme which encourages hybrid collaboration between science, technology and art. The art residency is organised as part of the research work carried out by the institution and some of the centres in the system. Organised in collaboration with Milan’s MEET Digital Cultural Center, it is one of 21 fellowships funded across Europe by the programme. The theme for the challenge was Preserving sustainability and inclusiveness in the co-evolution, that is: “How can we preserve the evolution of species by improving the ability of communities to be resilient?”. The greatest challenges of our time – issues such as mass extinctions, viral pandemics and climate change – serve as a reminder that we are intrinsically connected to our ecosystems. In her arts research, Sissel Marie Tonn has been exploring the relationship between our immune system and our constantly changing environment for some years, including with the help of immunologists and toxicologists. She has been talking to a number of researchers from Trieste’s research hub since March of this year. Among them are Alessio Ansuini and the research team working on data science and computing infrastructures at Area Science Park; Jacopo Grilli, a researcher at the ICTP working on theoretical and mathematical models to define the factors impacting terrestrial biodiversity; and Lisa Vaccari, an experimental scientist at Elettra Sincrotrone Trieste who uses various techniques in her research, from spectroscopy to microscopy, applying them to different study topics, from materials science to biology. Through the lens of an immersive, interactive animation, the artist will use the information gleaned from researchers and her upcoming visit to the labs at Area Science Park, to reconstruct a science-fiction universe in which humans share their immune response with all other species affected by microplastic pollution. As an allegory of the process of evolution, the project is intended to warn us against the profound consequences pollutants have on us and our ecosystem. The artist’s works will be on display to the public from October 2022 at the Maxxi Museum in Rome, the MEET Digital Culture Center in Milan, Ars Electronica in Linz (Austria) and ZKM, Center for Art and Media in Karlsruhe (Germany). “Researchers today have to be able to explain their research findings in a clear and understandable way to reach as many people as possible,” says Area Science Park President Professor Caterina Petrillo. “This requires exploring new languages, stimulating contamination between different disciplines – one of which is, without doubt, art, which has the same creative path as science. Bringing together these two seemingly disparate worlds stimulates new ideas and thought processes on both sides, which leads to new forms of innovation.”