Press releases

“Area Science Park is a hub for global, and above all Italian, knowledge, intelligence and expertise. It represents a concentration of our ability to excel. This area is the nucleus of a growing and ever stronger scientific community. A community that shows us again and again how powerful academic cooperation can be both for Italy’s innovation and as a diplomatic tool with international partners.” These were the words of the Minister for Universities and Research Anna Maria Bernini, during her visit to Area Science Park today, where she was welcomed by the President of the research institute, Prof. Caterina Petrillo, and General Manager Anna Sirica. Others present included the Regional Councillor for Research, Alessia Rosolen; the Mayor of Trieste, Roberto Di Piazza; the Prefect, Pietro Signoriello; and representatives of the scientific and technological institutions of SiS FVG, the Friuli Venezia Giulia Science and Innovation System. The President, Prof. Petrillo illustrated the core activities, strategic priorities and future development prospects of the research body to Minister Bernini, focusing on the investments that Area Science Park is making in the field of research and technological infrastructure. “We are very pleased that the Minister of Universities and Research has accepted our invitation to visit the institution and meet representatives of the Friuli Venezia Giulia Region’s Scientific and Innovation System,” commented President Caterina Petrillo after the meeting with the ministerial delegation. “Area Science Park is a national research institution under the aegis of the Italian Ministry of Universities and Research (MUR), with a unique profile and expertise developed over 45 years in the field of research and innovation serving the country. Today, thanks in part to funding from the MUR National Recovery and Resilience Plan, the institution is taking a further step forward, investing in new state-of-the-art equipment and attracting young talent. In fact, alongside two national partners, we are working on the finalisation of two research structures, one dedicated to the study of pathogens and another to the study of innovative materials.” Later, the Minister had the opportunity to visit some of the most important business and scientific entities at Area Science Park, starting with modefinance, a company with a technological and financial foundation, now part of the TeamSystem group. Modefinance is a native fintech company, founded in 2009 as a University of Trieste spin-off and incubated at Area Science Park, and develops artificial-intelligence and data-science solutions for credit risk assessment and management. Next was the ICGEB (International Centre for Genetic Engineering and Biotechnology), an intergovernmental organisation with 45 cutting-edge laboratories across three continents. It forms an interactive network of 68 member states, with operations aligned with those of the United Nations System. It plays a key role in biotechnology by promoting research excellence, training and technology transfer to industry, making a tangible contribution to global sustainable development. At ICGEB, welcomed by centre Director-General Lawrence Banks, the Minister visited the Tumour Virology, Bacteriology, and Functional Cell Biology laboratories. In the afternoon, the ministerial delegation moved to the Basovizza campus, where Minister Bernini visited Area Science Park’s Laboratory of Genomics and Epigenomics (LAGE), a leading national centre in the field of genomics and epigenomics and a key element of the Life Sciences Platform, an open research structure providing expertise and services aimed at experimental testing, and applied and industrial research projects, and which will be further enhanced thanks to MUR National Recovery and Resilience Plan funds. The next stop was the R&D laboratories of Alifax, one of the most important Italian companies specialising in the development, production and distribution of clinical diagnostic tools for laboratory automation, with a strong focus on scientific research and technological innovation supported by a constant programme of investments. Before leaving Area Science Park, the Minister visited Elettra Sincrotrone Trieste,the third-generation Italian synchrotron radiation facility serving the national and international scientific and industrial community. Alongside Elettra, since 2010 there has been Free Electron Laser FERMI, one of the few laser facilities of this type operational in the world, capable of ultrashort, microscopic observations at the atomic and molecular level. The Minister’s busy day ended with a visit to the icebreaker ship “Laura Bassi” of the OGS – National Institute of Oceanography and Applied Geophysics.

PICOSATS today announced the signing of a contract with the space logistics transportation company D-Orbit for the In-Orbit Demonstration of the RADIOSAT Ka-band transponder and the BEAMSAT K/Ka band horn antenna aboard the ION Satellite Carrier. ION Satellite Carrier is a multipurpose vehicle capable of performing satellite transport, payload hosting and advanced edge computing services in orbit in a single mission. The mission is scheduled for October 2023 and the target orbit is SSO, at an altitude of 500 – 600 km. “This opportunity will enable PICOSATS to reach flight heritage and enter the SATCOM equipment market with flight proven products” said Arianna Cagliari, VP Business Development. Founded in 2014 as a spin-off of the University of Trieste, PICOSATS is a company committed to the research, development, and commercialization of cutting-edge telecommunications systems for the small satellite market and beyond. The increasing use of small satellites in low orbits for satellite communications and the spectrum congestion has demanded the development of high-frequency, miniaturized telecommunications systems, and PICOSATS has seized the opportunity to enter this rapidly expanding market. PICOSATS is currently testing in an operational environment two transponders designed for CubeSats and small satellites, one in K/Ka and one in Ku-band for applications in LEO and GEO. The development of these products makes use of the know-how acquired by the company through various opportunities provided by the European and Italian Space Agencies. Along with the transponders, PICOSATS has also developed K/Ka-band and Ku-band horn antennas, and a V-band double reflector antenna for small satellites.

The kick off meeting at the Area Science Park officially got the “Pathogen Readiness Platform for CERIC-ERIC Upgrade” PRP@CERIC underway, the national project funded by Italian Ministry of Universities and Research (Ministero dell’università e della ricerca — MUR) within the National Recovery and Resilience Plan (Piano Nazionale di Ripresa e Resilienza — PNRR) and coordinated by the research institute Area Science Park in partnership with the National Research Council (Consiglio Nazionale delle Ricerche — CNR) (Institute of Materials [Istituto Officina dei Materiali] and Institute of Crystallography [Istituto di Cristallografia]), the University of Salerno, the University of Naples and the University of Salento. The project, which can count on funding of 41 million euro, aims to create a highly specialised research infrastructure, unique in Europe, which integrates instruments and expertise in biology, biochemistry, physics, bio-electronics, bio-informatics and data science to study pathogens of human, animal and plant origin and intervene quickly to prevent the spread of potential new outbreaks of diseases. A multidisciplinary approach is the key to achieving the fundamental and applied research objectives that the project aims to implement in compliance with the DNSH (Do No Significant Harm) principle, namely, not to cause significant harm to the environment. In line with practices already in place at the Area Science Park and Elettra Sincrotrone Trieste laboratories, both academic and industrial users will be provided open access to the new infrastructure for studies and analyses. PRP@CERIC provides for the construction of new laboratories, as well as the updating of existing instruments and services. In fact, the laboratories of Area Science Park, Elettra Sincrotrone Trieste, CNR and ICGEB (institutes of scientific excellence collaborating to implement the project) will be potentiated. The COVID-19 pandemic has highlighted the need to leverage solid scientific principles and interdisciplinary and international collaboration, which are all fundamental to successfully reducing the human, social and economic impact of potential future risks of epidemics. Research infrastructures can play a key role in understanding the fundamental aspects of pathogenicity and in the effective development of prevention and healthcare strategies. Cutting-edge instruments, methodologies and technologies on diverse and mutually integrated scales (from single molecules to whole organisms) have the potential to meet the sensitivity and selectivity requirements required by the study of complex biological systems, thus contributing to shedding new light on host-pathogen interaction mechanisms. “The PRP@CERIC project was developed based on the expertise in genomics and data science already present at the research institute, integrating these competencies with those of the Area Science Park system. I refer, for example, to the research excellence in the field of virology at the International Centre for Genetic Engineering and Biotechnology (ICGEB), as well as the experimental capabilities of the Electra synchrotron light source, a research centre of international importance”, commented the President of Area Science Park, Caterina Petrillo, during the project’s kick off meeting. “This consolidated scientific expertise is complemented by certain specialties at the universities of Naples, Salento and Salerno, partners with whom we have already developed projects of national importance. The integration of varied expertise and the networking of laboratories located in different geographical areas will create a unique infrastructure in Europe that will be at the service of the world of research and business, nationally and internationally”. The PRP@CERIC project, which will continue for 30 months, it also adheres to the FAIR (Findable, Accessible, Interoperable, Reusable) data guidelines, that is, the data produced will be processed in such a way as to be easily available, accessible, interoperable and reusable, in the spirit of open and collaborative science at an international level. Sustainability will also be extended to models of higher education, since the project involves the setting up of master’s course for graduates and training for the next generation of researchers. The “Pathogen Readiness Platform for CERIC-ERIC Upgrade” PRP@CERIC project is funded by the Italian National Recovery and Resilience Plan (PNRR) under Mission 4 “Education and Research”, Component 2 “From Research to Enterprise”, Investment Line 3.1 “Fund for the creation of an integrated system of research and innovation infrastructures”, funded by the European Union – Next Generation EU.

An international research team led by Milan’s Institute of Photonics and Nanotechnologies – part of the National Research Council (Cnr-lfn) – has used an innovative approach to investigate the chirality of molecules, an essential property to develop technologically innovative solutions in the fields of materials science, pharmaceutics, and catalysis processes. The study was conducted at the laboratories of the Elettra Synchrotron Research Centre in Trieste, home to the FERMI free-electron laser. This is a last generation instrument that has enabled chirality at the level of individual atoms to be “photographed” during an ultrafast process. The results of the study have been published in the scientific journal Physical Review X. “A chiral molecule is not superimposable on its mirror image: in other words, it is a molecule that does not have mirror symmetry, and that exists in two different forms, called enantiomers, which cannot be superimposed by rotation or translation”, explained Caterina Vozzi, director of Cnr-lfn. “Understanding this property is important to many aspects of chemistry, biology and physics: the chemical reactivity and biological and pharmacological activity of chiral molecules can vary significantly depending on the configuration of the enantiomers. In applications with these complex molecules, it is therefore important to understand how each atom contributes to total chirality, especially during chemical reactions”. In the study, the variation of the chiral properties of a molecule were analysed over time using the radiation produced by a free electron laser (FEL), a cutting-edge technology that produces extremely intense and short pulses of light, lasting a few femtoseconds (1 femtosecond corresponds to a millionth of a billionth of a second). “The FERMI free electron laser is the only one in the world capable of producing pulses of circularly polarized light capable of exploring these phenomena. This type of light is able to provide detailed information on the structure and dynamics of molecules, opening up new perspectives in basic and applied research ”, added Oksana Plekan, researcher at Elettra Sincrotrone Trieste, co-author of the study. “In this study, we have shown how the chirality of a molecule changes during an ultrafast process when we observe it from the perspective of the atoms forming it. This ability to observe chirality from multiple points of view is similar to stereoscopic vision in humans, thanks to which we can perceive the depth and three-dimensionality of the world around us”, stated Davide Faccialà, researcher at Cnr-Ifn and first author of the study. “The technique we have demonstrated enables us to observe in real time how the chirality of a molecule changes at an unprecedented level of detail, opening up new avenues for understanding the chemical and physical properties of chiral molecules in chemical reactions”. The study demonstrated the importance of combining expertise in different scientific fields to achieve innovative results in research. ———– The Italian Institute for the Structure of Matter (Istituto di struttura della materia — Ism) of the National Research Council (Consiglio nazionale delle ricerche — Cnr), the French National Centre of Scientific Research (Centre national de la recherche scientifique) and the University of Bordeaux (France), the University of Nottingham (UK), the German Electron Synchrotron (Deutsches Elektronen-Synchrotron) and the University of Hamburg (Germany), the Polytechnic University of Milan (Politecnico di Milano) (Italy), the University of Nova Gorica (Slovenia), the Sincrotrone Soleil (France) and the University of Tokyo (Japan) contributed to the research.

A close collaboration between scientific institutes and companies in the Friuli Venezia Giulia Region has produced promising results in the treatment of difficult wounds. A new advanced therapy for the effective resolution of difficult wounds has been published in the Nature group journal npj Regenerative Medicine. The study has shown how certain fat cells, named Stromal Vascular Fraction or SVF, are able to promote the formation of new blood vessels at the wound level, with important acceleration of healing time. Difficult wounds are extremely painful skin lesions that do not heal, and in fact worsen over time. This is caused by the coexistence of underlying chronic diseases, primarily diabetes and peripheral arterial disease, which do not allow adequate vascularization of the wound, which is necessary to ensure sufficient oxygen and nutrient supply, and thus healing. This is a common condition in people over 60, at least as common as heart failure, with major limitations in daily activities. The economic implications are important. About 3 percent of the global health budget is spent on the care of difficult wounds, which require specialized and expensive therapies: in Italy, more than 3 billion euros per year. Added to this is the reduction in the patient’s ability to work and the sometimes constant need for health care. This research, led by Serena Zacchigna, head of the Cardiovascular Biology Laboratory at the ICGEB and professor of Molecular Biology at the University of Trieste, was made possible by the PREFER project-Development of a Biocompatible PRoduct for the tErapy of Difficult FERites, funded by the 2014-2020 European Regional Development Fund Operational Program of Friuli-Venezia Giulia. In addition to ICGEB and UniTS, two regional companies, Zeta Research and Vivabiocell, led the project. “Currently available therapies are based on the application of skin substitutes to promote wound healing,” Zacchigna explains, “However, their effectiveness is limited by the inadequate vascularization that usually underlies this disease. How does this new therapy work? We took cells derived from the patients’ adipose tissue and applied them to the wound bed. After a few days, we observed the formation of a new vascular network, functional and connected with the pre-existing vessels.” “Restoring adequate blood supply to the wound is critical to support healing of the skin lesion,” continues Giovanni Papa, UniTS professor and Director of the Plastic Surgery Unit of the Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), which provided the cells and enabled validation of the efficacy. Collaboration between academia and business enabled this first milestone toward better care and quality of life for people with difficult wounds. Crucial to this journey was the participation of VivaBioCell, a leading manufacturer of bioreactors for cell therapies, which brought its industrial expertise and ability to transform research results into implementable solutions in a clinical reality. “The joint work between us academic researchers, hospital clinicians and the industrial research and development department was essential to define concrete goals that were compatible with the needs of the industrial scaling-up process,” says Roman Vuerich, first author of the paper and a doctoral student at UniTS and ICGEB. “This project was an example of how the synergy between academia and business can lead to concrete solutions to public health challenges.” “We are confident that this collaboration can continue in the future to bring an advanced therapy product to patients and serve as a beacon to promote other collaborative projects between research centers, hospitals and industry. Only through funding that supports the synergy between these entities will we be able to ensure that research results reach patients and that this can also happen in Italy,” Zacchigna and Papa concluded in unison. Link to the paper.

Trieste, 20 December 2022 – The research programme REFIBER, developed by Area Science Park and Innovando srl landed in Paris, as part of efforts to establish a national recycling chain for fibreglass boat hulls. The meeting took place at the recent Paris Boat Show, one of the most important events in the sector, seeing some 150,000 visitors and 650 exhibitors in attendance. “We met with representatives of the ‘Association pour la Plaisance Eco-Responsable (APER)’, the French consortium for collecting and dismantling pleasure boats and watercrafts, which today represents European best practice in the sector,” said Marcello Guaiana,president of the Temporary Association of Scope implementing the REFIBER programme. Our goal is to find the convergence between our research initiative and APER’s operations, to jointly evaluate innovative technologies for recycling materials from dismantling, and solutions for replacing critical materials to improve the sustainability of these vessels.” How to decommission and manage the disposal of end-of-life pleasure crafts is a major environmental, and socio-economic, issue. To date, there is still no structured collection model in Italy to correctly manage 10-24 m boats at the end of their life. So much so that, over the last ten years, only a very small percentage of the approximately 10,000 vessels removed from the official registers have been properly managed. The aim of REFIBER is to create a hub to concentrate and exploit the flows of materials left after a boat has been decommissioned. One of these materials is fibreglass, a multi-layered material made up of plastic and glass, which accounts for the largest proportion at 60% by weight and is the most difficult to process. One management model being analysed as part of the programme is the Extended Producer Responsibility (EPR) model, already well established in other fields. This model involves both the manufacturers and distributors from within the sector. “We want to contribute, in a coordinated way, to a harmonised development of European sector standards,” said Ivana Lazarevic, deputy director general of APER. “By working together, it will be easier to establish and share communication and awareness-raising activities with national and international stakeholders.” At this stage, the focus of the REFIBER programme is pleasure boats, but the system may be opened up to include vessels under 10 metres in the future. Francesco Di Pierro and Cveta Majtanovic of Innovando both hope that, “better mutual communication can speed up implementation of the REFIBER programme, building on APER’s many years of experience with private operators and public institutions, and sharing more good operating practices”. “In the medium term,” concluded Matilde Cecchi of Area Science Park, “we will be able to assess the optimum conditions for promoting and implementing collaborative initiatives and research projects aimed at experimenting with new technologies, to make the nautical sector more sustainable”.

The Mediterranean region warms 20% faster than other regions in the world and local authorities are at the forefront of the actions for adapting to and mitigating the multiple impacts of climate change. To this end the Urban Transports Community*, an Interreg MED Programme initiative, promotes sustainable urban mobility planning in the Euro-Mediterranean region as an effective tool to reduce carbon emissions and improve the quality of life of the population and the environment. The Community has gathered together almost 200 organisations (public authorities, associations, mobility planners, universities and international organisations, amongst others) from 12 Euro-Mediterranean countries. In support of local authorities it has elaborated and published a selection of tools and solutions with the highest replicability potential. As part of the project, the Area Science Park experts have developed several reports which constitute reference guides and a scientific basis for policy makers and urban planners to develop the planning of mobility and related infrastructures. Urban mobility Adaptation to Climate Change is the topic of the latest policy brief presented on December 14th 2022 during the online event “Mediterranean cities and climate change: making the urban transport sector more resilient and less impactful”. The policy brief describes the main impacts of climate change on urban mobility, with the aim of raising awareness among policy makers, suggesting possible solutions to minimize its effects and make the mobility system more resilient to climate change. Transport infrastructures will be exposed, in the next decades, to an increasing number of new challenges from climate impacts. Panning today for the construction of new and the management of existing infrastructures will require the consideration of new environmental, climatic and socio-economic parameters and conditions with respect to those used in the past. During the project Area Science Park drafted two other technical reports. The first one focused on the analysis of technological trends relating to electric vehicle charging infrastructure, and the second one on the spread of automated vehicles in the cities. The reports are available here: https://urban-transports.interreg-med.eu/policy-briefs/ *The Urban Transports Community is featured by a project led by MedCities (Barcelona, Spain), in partnership with UNIMED Mediterranean Universities Union (Rome, Italy), Area Science Park (Trieste, Italy), CODATU (Lyon, France), CIVINET CY-EL (Cyprus-Greece), POLIS, Cities and Regions for transport innovation (Brussels, Belgium), and Durres Municipality (Durres, Albania).

Alzheimer’s disease is not the same for men and women: certain molecular mechanisms in fact differ between the two sexes, particularly in terms of metabolism of an amino acid that has recently been proposed as an early marker of this disease and which would therefore not be equally reliable for men and women. These are the findings of an Italian study published in “Cell Reports” in September and led by the University of Milan, with collaboration of the Insubria University, University of Milano-Bicocca, Rome’s Tor Vergata University and the Area Science Park Genomics and Epigenomics Laboratory (LAGE). The research paves the way for distinct and personalised treatment based on gender. Researchers analysed post-mortem samples from the brains of men and women with normal ageing and from patients of Alzheimer’s disease. Area Science Park’s contribution, explains Danilo Licastro, Head of LAGE, was focused on genomic and epigenomic analysis. The greatest challenge was to define and implement an analysis protocol that was compatible with the RNA tissue samples sent by the University of Tor Vergata and previously provided by biobanks, because this post-mortem tissue did not present the same quality as fresh tissue. Analysis highlighted marked differences in terms of the metabolic pathways altered. Two examples are insulin response and metabolism of the amino acid serine (which generates an important regulator of cerebral function, D-Serine). This is of particular interest because D-Serine modulates neurotransmission and also because its levels in the blood have been proposed as an early marker of this disease. “These results demonstrate how Alzheimer’s changes and, in certain aspects, inverts some features in the two sexes”, commented Elisa Maffioli, from the University of Milan, “highlighting how different mechanisms are active or not based on gender and opening the possibility of treatment with innovative approaches that differ for men and women”.   Read the whole article: Insulin and serine metabolism as sex-specific hallmarks of Alzheimer’s disease in the human hippocampus

From 16th to 20th May, Danish artist Sissel Marie Tonn has been guest at Area Science Park’s labs to work on her art residency project “The Sentinel Immune Self”. She is the winner of the “Preserving co-evolution” challenge organised as part of the European S+T+ARTS programme. S+T+ARTS (Science + Technology + Arts) is a European Commission initiative launched under the Horizon 2020 programme which encourages hybrid collaboration between science, technology and art. The art residency is organised as part of the research work carried out by the institution and some of the centres in the system. Organised in collaboration with Milan’s MEET Digital Cultural Center, it is one of 21 fellowships funded across Europe by the programme. The theme for the challenge was Preserving sustainability and inclusiveness in the co-evolution, that is: “How can we preserve the evolution of species by improving the ability of communities to be resilient?”. The greatest challenges of our time – issues such as mass extinctions, viral pandemics and climate change – serve as a reminder that we are intrinsically connected to our ecosystems. In her arts research, Sissel Marie Tonn has been exploring the relationship between our immune system and our constantly changing environment for some years, including with the help of immunologists and toxicologists. She has been talking to a number of researchers from Trieste’s research hub since March of this year. Among them are Alessio Ansuini and the research team working on data science and computing infrastructures at Area Science Park; Jacopo Grilli, a researcher at the ICTP working on theoretical and mathematical models to define the factors impacting terrestrial biodiversity; and Lisa Vaccari, an experimental scientist at Elettra Sincrotrone Trieste who uses various techniques in her research, from spectroscopy to microscopy, applying them to different study topics, from materials science to biology. Through the lens of an immersive, interactive animation, the artist will use the information gleaned from researchers and her upcoming visit to the labs at Area Science Park, to reconstruct a science-fiction universe in which humans share their immune response with all other species affected by microplastic pollution. As an allegory of the process of evolution, the project is intended to warn us against the profound consequences pollutants have on us and our ecosystem. The artist’s works will be on display to the public from October 2022 at the Maxxi Museum in Rome, the MEET Digital Culture Center in Milan, Ars Electronica in Linz (Austria) and ZKM, Center for Art and Media in Karlsruhe (Germany). “Researchers today have to be able to explain their research findings in a clear and understandable way to reach as many people as possible,” says Area Science Park President Professor Caterina Petrillo. “This requires exploring new languages, stimulating contamination between different disciplines – one of which is, without doubt, art, which has the same creative path as science. Bringing together these two seemingly disparate worlds stimulates new ideas and thought processes on both sides, which leads to new forms of innovation.”