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TEAM RIT
Giuditta De Lorenzo
Researcher at Technological Innovation Research Institute

My research interest lies at the intersection of molecular virology and structural vaccinology. As Head of the Virology Unit at the Research and Innovation Technology Institute (RIT), Area Science Park in Trieste, I lead the development of innovative countermeasures against emerging viral threats.
During my previous position at the MRC-University of Glasgow Centre for Virus Research (CVR- Scotland), I supervised the design and preclinical evaluation of a Zika virus vaccine candidate while characterizing the phenotypic impact of viral mutations. Building on this expertise, my unit now collaborates with the Laboratory of Data Engineering to pioneer AI- and structure-guided approaches for rational antigen design, focusing on viral envelope dynamics and neutralizing monoclonal antibody discovery.
In addition, I supervise research into the mechanisms by which emerging SARS-CoV-2 mutations alter the cellular DNA damage response, inflammation, and senescence pathways. In collaboration with the University of Trieste, we also evaluates novel broad-spectrum antiviral peptides targeting priority arboviruses.

Research Interest
  • Arboviruses
  • Coronaviruses
  • Vaccine development
  • Antibody discovery
  • Antiviral peptides
  • Antiviral response
Experience & Education
  • Research Associate at MRC-University of Glasgow Centre For Virus Research (CVR), 2020
  • Research Assistant at MRC-University of Glasgow Centre For Virus Research (CVR), 2016
  • PhD in Molecular Genetics and Biotechnology at University of Nova Gorica, 2016
  • MSc in Functional genomics at University of Trieste, 2011
Projects
13/05/2026
Vir-Watch FVG
West Nile Virus (WNV) and Tick-Borne Encephalitis Virus (TBEV) are RNA viruses belonging to the…
Go to the news Vir-Watch FVG
28/01/2025
Impact of SARS-CoV-2 variants on genome integrity and their involvement in inflammation and neuropathogenesis
Severe COVID-19 is characterized by the inefficient suppression of early stages of infection followed by…
Go to the news Impact of SARS-CoV-2 variants on genome integrity and their involvement in inflammation and neuropathogenesis
28/01/2025
AntiViralStress – Investigating the synergetic role of ER stress in mounting an antiviral response
Cellular response to Endoplasmic Reticulum (ER) stress plays a role in virus infection in more…
Go to the news AntiViralStress – Investigating the synergetic role of ER stress in mounting an antiviral response
09/03/2023
PRP@CERIC ERIC – Pathogen Readiness Platform for CERIC-ERIC Upgrade
The project “Pathogen Readiness Platform for CERIC-ERIC Upgrade” (PRP@CERIC) aims to strengthen the CERIC-ERIC Research Infrastructure through…
Go to the news PRP@CERIC ERIC – Pathogen Readiness Platform for CERIC-ERIC Upgrade
Latest pubblications
25/04/2025
Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models
Abstract Zika virus (ZIKV) remained poorly studied until an outbreak in 2015 linked the virus…
Go to the news Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models
21/01/2025
Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion
Abstract Coronaviruses express their structural and accessory genes via a set of subgenomic RNAs, whose…
Go to the news Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion
03/01/2025
Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic
Abstract SARS-CoV-2 variants are mainly defined by mutations in their spike. It is therefore critical…
Go to the news Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic
02/04/2024
Virus-like particles of louping ill virus elicit potent neutralizing antibodies targeting multimers of viral envelope protein
Abstract Louping ill virus (LIV) is a tick-borne flavivirus that predominantly causes disease in livestock,…
Go to the news Virus-like particles of louping ill virus elicit potent neutralizing antibodies targeting multimers of viral envelope protein
16/02/2024
Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human adaptation resulted in distinct lineages with…
Go to the news Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants
17/11/2023
Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continued to evolve throughout the coronavirus…
Go to the news Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning
12/10/2023
SARS-CoV-2 variants evolve convergent strategies to remodel the host response
Abstract SARS-CoV-2 variants of concern (VOCs) emerged during the COVID-19 pandemic. Here, we used unbiased…
Go to the news SARS-CoV-2 variants evolve convergent strategies to remodel the host response
23/08/2023
Multiplexed biosensing of proteins and virions with disposable plasmonic assays
Abstract Our growing ability to tailor healthcare to the needs of individuals has the potential…
Go to the news Multiplexed biosensing of proteins and virions with disposable plasmonic assays
21/06/2023
Antiviral evaluation of new synthetic bioconjugates based on GA-Hecate: a new class of antivirals targeting different steps of Zika Virus replication
Abstract Re-emerging arboviruses represent a serious health problem due to their rapid vector-mediated spread, mainly…
Go to the news Antiviral evaluation of new synthetic bioconjugates based on GA-Hecate: a new class of antivirals targeting different steps of Zika Virus replication
20/04/2023
Evaluation of an engineered zika virus-like particle vaccine candidate in a mosquito-mouse transmission model
Abstract The primary route of Zika virus (ZIKV) transmission is through the bite of an…
Go to the news Evaluation of an engineered zika virus-like particle vaccine candidate in a mosquito-mouse transmission model