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Area Science Park will once again participate in organising the national mission that will take the best Italian tech startups to CES in Las Vegas, the world’s most important tech fair, scheduled from 7 to 10 January 2025. The national research institution will collaborate with ICE – the Italian Trade Agency for the promotion abroad and internationalisation of Italian companies – to assist the 48 startups in the Italian Pavilion, set up inside the Eureka Park, the CES area dedicated to emerging innovations. Since 2018, Area Science Park has been supporting this mission, which offers startups a tangible opportunity to engage with the global market and with potential research and industrial partners. It is a stage that allows companies to validate their solutions directly in the field, interacting with key operators and investors. This year, Area Science Park has once again organised the Startup Academy, a series of training and capacity-building sessions with experts from the world of innovation, aimed at preparing the startups to get the most out of their experience at CES: from organising the event and the best ways to interact with potential research and industrial partners, investors and the press to contractual and legal aspects, media relations management and pitching techniques. This activity is part of the deep tech innovation development initiatives, favouring strategic sectors such as life sciences, materials science, advanced digital technologies and green energy supply chains, to support business generation and promote the socioeconomic development of the national territory by connecting research and business. During CES, Area Science Park will also play a key role in the lineup of events, workshops and conferences taking place in the Arena of the Italian Pavilion, where numerous international stakeholders from the technology sector will be speaking. Participation in CES is part of Area Science Park’s strategy to support the growth of Italian tech companies. Among the most recent initiatives was the fifth edition of the Startup Marathon, held in collaboration with UniCredit and Fondazione Comunica, which ended with the final event on 26 November in Milan, demonstrating the institution’s commitment to creating connections between startups, research, industry and investors, while stimulating open innovation within the economic fabric and the development of small innovative businesses.

The fourth edition of the annual report, created by DITEDI in collaboration with scientific partners Area Science Park (Enrico Longato, Innovation Intelligence FVG), the University of Trieste (Guido Bortoluzzi and Lorenzo Porta) and the University of Udine (Maria Chiarvesio and Martina Tomasetig), with the collaboration of the Autonomous Region of Friuli Venezia Giulia, was presented at the new P. Maurensig immersive theatre in Tavagnacco. The FVG Digital Report 2024 entitled “Business Strategies in the Era of AI: How IT Companies Face and Change the Market” analyses and describes how the numerous small and medium-sized companies within the FVG digital landscape are creating new product and service offerings linked to Artificial Intelligence and how they use it to customise solutions that can impact their clients’ products and production processes, either independently or by using collaborative forms, including business networks, to bring this technology into the regional production fabric. The 2024 data shows consistent and steady growth of ICT companies becoming established across the region, totalling 2,908, an increase of 2.4% compared to 2022, with a total of 2,214 companies in Friuli Venezia Giulia operating in the ICT sector, marking a 0.9% increase compared to 2022. The province of Udine represents the area of reference for regional ICT businesses, as it contains nearly half of those identified. Corporations (1,056 entities) represent the dominant company structure, accounting for 47.7% of the total, up 1.7% since 2022. These are followed by sole proprietorships (812 entities, 36.7%), which show a more significant nominal increase, with 31 additional businesses compared to 2022. The regional digital sector serves as a strong driver of innovation for the economy and the regional business system. In fact, the ICT sector currently includes 102 innovative startups, operating mainly in software development and representing 52% of all regional startups, demonstrating the importance of the sector in driving innovation. Other similar signs can be seen in the innovation propensity indicator, which reveals that 13% of regional ICT companies exhibit at least one sign of innovation. These companies account for 9% of all regional businesses with an objective propensity for innovation. Alongside the analysis of economic data and the growth dynamics of the sector, with insights into creditworthiness (ratings), the report features 12 significant business cases illustrating how regional companies are integrating AI to develop products, optimise processes and expand their markets (companies represented: AI4IV, Aindo, Datamantix, Datamind, Evoseed, eXact Lab, Eye-Tech, Infostar, Motion Analytica, NT Nuove Tecnologie, Visiofy and Visup). The FVG digital ecosystem thus appears to be growing and ready for the AI challenge, and the innovative drive not only affects products and services but also business models and relationships. The full report is available here.

The first call for the NFFA-DI infrastructure, announced in September, ended successfully on 10 November, with the active participation of 81 researchers from 28 research institutes, universities and small and medium enterprises (SMEs), as well as four international institutions. NFFA-DI is a research infrastructure distributed across Italy and was created thanks to funding by the National Recovery and Resilience Plan (PNRR), which integrates cutting-edge instrumentation, computational resources and scientific data management in line with “Fair” and open science principles. Working alongside the eight operational units of the National Research Council (CNR), which coordinates the project, are those of the partner institutions: Area Science Park, the Polytechnic University of Milan and the University of Milan. These 11 operational units are centres of excellence in nanoscience and nanotechnology in Italy. In the first call, 29 research projects were presented, leveraging the capabilities of the consortium’s five distributed installations, made available through its 11 access points, also using them in combination with each other to obtain innovative results. The topics covered span across various cutting-edge scientific areas, including Physics, Chemistry, Materials Science, Engineering and ICT. Applications range from quantum technologies to biotechnology applied to diagnostics, sustainable energy solutions, hybrid materials research in nanotechnology and photonics. These areas of research are crucial for developing innovative solutions to global challenges such as sustainable energy, advancements in medical technologies and innovation in electronic devices and communications, as well as enhancing computational capabilities. The projects submitted involve not only basic research but also applied research, with two projects explicitly expressing industrial interest. A total of 45 experimental sessions were requested in the first call, corresponding to 260 days of access to the facilities. Notably, young researchers made up approximately one third of the participants, highlighting the importance of NFFA-DI as a valuable opportunity for researchers in the early stages of their careers to engage with state-of-the-art techniques and advanced instrumentation, supported by industry experts. The second call for the project is now open and will close on 15 April 2025. Key numbers: 29 Projects submitted (2 of industrial interest) 45 Experimental sessions requested 260 Days of access to the infrastructure requested 18 Different scientific techniques 28 Institutions (2 SMEs and 4 foreign institutions) 81 Users (of which one third are young researchers: students, PhD students, post-docs) (Source: CNR)

A dynamic sector, ready to face the challenges of innovation and diversification. These are the findings of Comet’s report on the Friuli Venezia Giulia Metalworking Industry Observatory presented on 27 November in Valvasone Arzene, at the TreZero Winery. The meeting was divided into two round tables: in the first one, moderated by Cluster Comet director Saverio Maisto, the report was illustrated by Enrico Longato (Area Science Park), Anna Maria Moressa (Intesa Sanpaolo), Maria Chiarvesio (University of Udine), Guido Bortoluzzi (University of Trieste); the second round table, moderated by Michele Valerio (Eupragma), gave voice to businesses, with Stefano Picinich (Airworks Srl), Matteo Querini (Eurolls SpA), Elisa Quattrin (Meccanica Hi-Tech Srl), Alessandro Sist (Siom Srl SB). The event was organised in partnership with Area Science Park, University of Trieste, University of Udine, Intesa Sanpaolo. The meeting highlighted three main topics: – An international vocation The metalworking sector accounts for 46% of regional manufacturing, with an electro-mechanical specialisation (94% of metalworking sector). As of November 2024, the industry ‘held up’ better than predicted in the June flash report, with 5,114 businesses (-0.3% compared to November 2023, instead of -0.7%), while the rest of the manufacturing sector performed in line with expectations. The province of Udine accounts for 45% of the regional companies, the area that has recorded the most significant decrease since 2021 (-2.3%). The province of Pordenone remains stable, with 32% of the companies. The tendency towards internationalisation remains strong (41% of companies); exports are prevalent among medium and large companies, which are often innovative and certified. – Diversification and economic performance Intesa Sanpaolo’s internal survey regarding its commercial network shows that businesses in Friuli Venezia Giulia are increasing the geographical diversification of their outlet and supply markets, exceeding the Italian average. In 2023, revenue growth at current prices was 22.5%, with an improvement in profit margins (+2 points compared to 2019), driven by foreign operations (25.9% growth) and participation in the construction industry. – Business diversification strategies In a rapidly evolving market, businesses in Friuli Venezia Giulia interviewed by the Universities of Udine and Trieste are experimenting with new strategies: some focus on geographical or sectoral diversification to grow or to avoid crises, while others are strengthening their presence in current markets. However, diversification requires transversal skills and the ability to adapt to the rules of the new markets, which not all companies possess. ‘Over the years, the metalworking industry in Friuli Venezia Giulia has managed to acquire a role of excellence at the international level, thanks to its solid tradition of craftsmanship skills and technological innovation,’ commented COMET Cluster Director, Saverio Maisto. ‘However, today we face an even greater challenge: the world is changing at an exponential speed, global scenarios are complex, and what has made us strong so far may no longer be sufficient to guarantee continuing success. This is how we have always worked; it is no longer a security, quite the contrary. The ability to adapt and anticipate the future is crucial. We have to look beyond the boundaries of the traditional and historical sectors in which we have been, and perhaps still are, leaders, exploring new markets that, while initially presenting themselves as challenges, may turn out to be extraordinary opportunities. This is why it becomes essential to diversify, not only strategically but also in the immediate future. ‘Only by embracing new sectors and markets, continuing to collaborate with the territory, innovating and consolidating our skills, businesses in Friuli Venezia Giulia can continue to play a leading role in our history. “The future of the Friuli Venezia Giulia metalworking sector will depend on its ability to combine tradition and innovation, diversifying markets and sectors and integrating emerging technologies. The cooperation and support of COMET will be central to ensuring competitiveness and resilience in global markets,’ concluded Comet President, Sergio Barel. He emphasized how the Friuli Venezia Giulia metalworking sector is facing the challenges of a complex economic and geopolitical context through geographical and sectoral diversification. This key strategy reduces dependence on traditional markets, such as the German one, and opens up new opportunities in areas of higher growth (Northern Europe, Asia, the United States) thanks to niche technical skills and high-quality production), and regulated sectors (aerospace, medical, defence). As for artificial intelligence, which is transforming the sector by improving quality, supply chain and innovation, ‘it, requires investment in training and infrastructure’. The president closed his speech by inviting companies, industrial clusters, universities and institutions to build networks.

For the first time, direct evidence of the use of psychoactive substances during rituals in the Ptolemaic Kingdom in Ancient Egypt has been provided. The discovery, published in the journal Scientific Reports, is based on the analysis of a ritual vase over 2,000 years old, which revealed traces of psychoactive plants used in religious and spiritual practices. The vase is adorned with the head of the Egyptian god Bes, a grotesque but benevolent deity often used as a protective amulet for the home. The research, coordinated by Professor Enrico Greco from the University of Trieste, in collaboration with the Tampa Museum of Art, the University of South Florida and the University of Milan, was made possible thanks to the crucial support provided by Elettra Sincrotrone Trieste, which contributed with advanced techniques, such as Fourier transform infrared spectroscopy (SR µ-FTIR) coupled with synchrotron radiation. Chiaramaria Stani, CERIC-ERIC researcher at Elettra Sincrotrone Trieste’s SISSI beamline, explained: “These analyses made it possible to identify the ceremonial content of the vase, although the residual traces were minimal, but well preserved in the porosity of the pottery”. This technology made it possible to analyse the residual traces inside the vase, revealing the presence of plants such as Peganum harmala (Syrian rue), Nymphaea nouchali (blue lotus) and species of the Cleome genus, all known for their psychoactive properties. The analysis also indicated that the vase was used in rituals involving the achievement of altered states of consciousness, probably a means for communicating with the divine and facilitating mystical-ritual experiences. The research not only confirms previous hypotheses based on texts and iconography but it also provides solid physical evidence of the sophisticated use of natural substances by the Egyptians. The multidisciplinary approach, combining science, history and culture, was essential for solving this ancient mystery, confirming the importance of collaboration between research institutes like Elettra Sincrotrone Trieste and the universities involved.

Scientific collaboration between Italy and Serbia is being strengthened. The Minister of University and Research, Anna Maria Bernini, and the Serbian Minister of Science, Technological Development, and Innovation, Jelena Begović, inaugurated the second Italy-Serbia Scientific Forum in Trieste at Area Science Park, with the participation of over 100 researchers from both countries. Following a bilateral meeting, the ministers signed a joint declaration confirming the importance of cooperation in research and innovation, based on the MoU signed in Belgrade in 2023, as well as the promotion of researcher mobility, support for joint research programs, and bilateral scientific events. The document also highlighted the great success of the first call for joint research projects focused on the following areas: High Performance Computing and Big Data, Artificial Intelligence, Agri-food Technologies, and Sustainable Economy. Over 80 applications were received and are currently under evaluation. The selected projects will be co-financed by both countries (for a total of 2 million euros) at the beginning of 2025. Today’s event continues the path started in March 2023 in Belgrade when Area Science Park participated in the first edition of the Science Forum. In December 2023, during the Innovation Forum, a Memorandum of Understanding was signed in the capital between Area Science Park and the science and technology parks of Belgrade, Niš, Čačak, and Novi Sad. This memorandum further develops a longstanding cooperation with Serbia that began in 2015, focusing on technical assistance in the fields of technology transfer and economic development. The goal is to pool scientific and technological capacities, such as those generated by research infrastructures and technological platforms, for example, on topics like life sciences, energy transition, and innovative materials. “The Italy-Serbia scientific forum represents, for Area Science Park and for the entire Scientific and Innovation System of Friuli Venezia Giulia, an important opportunity to strengthen collaboration between the two countries and create new opportunities for the exchange and sharing of knowledge and best practices,” said Caterina Petrillo, President of Area Science Park. “In particular, for the institution I lead, hosting, and especially participating in the forum, means expanding the areas of exchange and dialogue with research centers, universities, and science and technology parks, with which we have previously developed innovation projects. Today, our attention is focused on research and technological infrastructures, where Area has been investing in recent years, which by their nature are places for aggregation and sharing of knowledge.”

A robotic device that uses ultrasound technology to treat liver cancer, one of the world’s leading causes of death, with over 900,000 cases every year. The Pisa-based startup Soundsafe Care has won first prize in the 2024 Startup Marathon. The startup competition, promoted by Area Science Park, UniCredit and Fondazione Comunica, ended on Tuesday, 26 November, with an event hosted at the UniCredit headquarters in Milan. Ten finalists were selected by a jury of entrepreneurs, investors and industry experts, from a pool of over 60 startups and innovative SMEs, enrolled in the competition by incubators, accelerators, research centres and universities all over Italy. Awards for Startups Operating in the artificial intelligence, innovative materials, nutraceutical, agritech, healthcare, gaming, electric mobility and medical innovation sectors, the ten startups competed for access to the UniCredit Start Lab acceleration programme. The overall winner, Soundsafe Care, is a company supported by the Navacchio Technology Hub. Using focused ultrasound, the device developed by the startup provides a non-invasive and drug-free alternative for the treatment of liver cancer, reducing complications and hospital costs. Thanks to advanced imaging and automation technology, the device improves treatment precision and reduces intervention times. Soundsafe Care also received the award for the best predominantly female startup, guaranteeing participation in the BoostHerUp internationalisation programme, promoted by Area Science Park. In second place was another med-tech startup, Impavid from Turin, nominated for the contest by G-Factor, the Fondazione Golinelli business incubator. Impavid develops an innovative biodegradable cardiac patch to combat post-ischaemic heart failure. This biomimetic and bioresorbable patch recreates the structure of myocardial tissue, promoting cell recovery and adapting to the heart’s rhythm. Initially designed for bypass procedures, it offers a safer and less invasive solution to improve patients’ quality of life. With strong potential in the US and European markets, the product responds to the growing demand for advanced cardiology technologies. Ranked third, the Lecce-based BeadRoots – supported by Eatable Adventures – develops a natural and biodegradable hydrogel derived from algae. This hydrogel efficiently retains and releases water to improve agricultural productivity and reduce water wastage, especially in areas affected by drought. Unlike synthetic products, the gel is eco-friendly and supports soil microorganisms without negative impacts. The startups on the podium will have the opportunity to enjoy privileged access to the pre-selection stage for the national mission at CES in Las Vegas. Awards for support organisations The top three business support organisations that nominated startups for the event were also rewarded. Points were assigned based on the ranking of the startups, with a bonus for the placement of predominantly female startups. The first prize went to the Polo Tecnologico di Navacchio, followed by G-Factor in second place and Eatable Adventures in third place. All three were granted privileged access to the Executive MBA in Business Innovation created by the MIB Trieste School of Management. This same recognition was awarded individually to all 10 finalist startups. The 2024 edition also introduced the Open Innovation B2B competition, which challenged startups and innovative SMEs to respond to specific innovation needs indicated by corporate partners of the initiative. “We are very pleased with this fifth edition of Startup Marathon”, said Roberto Pillon, head of the Business Generation Office at Area Science Park. “The startups selected for the finals operate in very diverse sectors, showing how innovation is a cross-cutting element in every market and how initiatives like this can support its development. Today, the transformative capabilities of technology, with the even greater potential of the deep-tech sector, have an enormous impact on every industry: a scenario that can be expressed in full through close collaboration between producers of innovation and businesses capable of leveraging it.” Renzo Chervatin, head of Territorial Development for UniCredit North Est, stated: “There are many reasons to feel satisfied with the 2024 edition of Startup Marathon, particularly the creation of a virtuous ecosystem made up of corporate companies, investors and numerous accelerators and incubators at the national level. As UniCredit, we have made available the know-how gained in over a decade as pioneers and leaders supporting the world of Italian startups, with the intent of reaffirming, in practice, our commitment to work alongside those who want to invest in innovation, by proposing growth opportunities to businesses and jobs to young people.” Gianni Potti, President of Fondazione Comunica and founder of DIGITALmeet, added: “This is a brilliant demonstration of digital literacy, one of the biggest challenges for the country. In addition to this, there are also innovation and entrepreneurial skills, requirements that the Jury used for the 2024 edition of Startup Marathon: as of September, there were 16,500 innovative startups in Italy; at the same time, there were nearly 200 thousand in Europe, concentrated in the technology, sustainability, digital health and artificial intelligence sectors. Startups are a fundamental driving force for the future, thanks to their ability to innovate, adapt and transform entire sectors.” “This is yet another demonstration of an idea that turned out to be spot on”, commented Antonio Bassi and Maurizio Caradonna, founders of Startup Marathon, “The Startup Marathon final, attended by a high-profile audience, showcased entrepreneurial ventures with great opportunities for development and teams with high-level skills and technological knowledge, supported by organisations that aim to create high-potential businesses throughout the nation. We are proud to have contributed, even in a small way, to encouraging the growth of this innovation ecosystem”.  Startup Marathon was founded in 2020 and, over the years, it has selected and rewarded innovative companies operating in sectors such as artificial intelligence, diagnostics, IoT and sustainability. Winners of past editions include Katakem, a spin-off of the University of Catanzaro, that accelerates the development of new molecules, CAEmate, a company that has developed software for the predictive maintenance of infrastructures, Aisent, which provides services based on AI, machine learning and computer vision, and M2Test, a spin-off of the University of Trieste that has created an innovative method for diagnosing osteoporosis. Partners In addition to the three promoters, several partners support Startup Marathon, including Angel For Women, ASAC, Avvio Capital, Bando Easy, Camst Group, Carel, Chiesi, CRCLEX, DBA Group, Eatable Adventures, ELIS Innovation Hub, Eurotherm, Fastweb, FITT, Galdi, Giordano Controls, HiRef, Italian Angels for Growth, Italian Business Angels Network, LIFTT, Manni Group, Master Builders Solutions, Mastercard, Maxfone, MIB Trieste School of Management, MITO Tech Ventures, One Factory, San Marco Group, Star Tech Ventures, Step, Unicorn Trainers Club, Venture Factory and WDA.   The Finalist Startups and their Supporting Organisations BeadRoots, Lecce, supported by Eatable Adventures Cartesia Solutions, Pisa, supported by Digital Hub Impavid, Turin, supported by G-Factor InnoItaly, Codognè (Treviso), supported by Trentino Sviluppo Joule, Campodarsego (Padua), supported by Seedble Northern Light Composites, Monfalcone (Gorizia), supported by TEC4I FVG NuHpro, Rimini, supported by CesenaLab SoundSafe Care, Pisa, supported by Polo tecnologico di Navacchio Weabios, Pisa, supported by Polo tecnologico di Navacchio Witty Power, Bolzano, supported by NOI Techpark   Startup Marathon is a competition for innovative businesses, open to startups, innovative SMEs and university spin-offs nominated by business incubators and accelerators. Promoted by Area Science Park, UniCredit and Fondazione Comunica, it has been selecting the most significant innovative Italian companies since 2020, accelerating their go-to-market journey.

An international study, involving the Italian National Research Council (CNR – Istituto Officina dei Materiali) and the Universities of Trieste and Milano-Bicocca for Italy, along with the University of Vienna, has unveiled a simple and innovative method for creating a new category of materials. These materials combine the exceptional properties manifested by individual metal atoms with the robustness, flexibility and versatility of graphene, for potential applications in the fields of catalysis, spintronics and electronic devices. The study is published in Science Advances: the method involves depositing metal atoms, such as cobalt, in a controlled manner, during the formation of the graphene layer on a nickel surface. Some of these atoms are incorporated into the carbon network of graphene, forming a new material with exceptional robustness, reactivity and stability. The method was developed at the CNR-IOM laboratories in Trieste: “This is still a preliminary result, but it is already very promising and the result of an original idea that arose in our laboratory and initially seemed unfeasible,” says Cristina Africh, a researcher at the CNR-IOM who led the team. The material’s ability to detach from the substrate while maintaining its original structure makes it potentially usable in various applications. “The methodology has been tested for trapping nickel and cobalt atoms, but our calculations suggest that it could be extended to other metals for different applications,” explains Cristiana Di Valentin, professor of General and Inorganic Chemistry at the University of Milano-Bicocca. Moreover, the material has proven to be stable even under critical conditions. “We have demonstrated that this material remains intact even in critical conditions, including the electrochemical environments used for applications in fuel cells and batteries,” adds Jani Kotakoski of the University of Vienna. The study, which is the result of international collaboration, made use of different and complementary skills. “This aspect was decisive in demonstrating the effectiveness of this approach, which is simple and powerful at the same time,” concludes Giovanni Comelli from the University of Trieste.

An international forum dedicated to the value and role of large research infrastructures in scientific progress and their economic, social and geopolitical impacts on a global scale. These were the central themes of the G7 conference “Large Research Infrastructures: Synergies and Impact on Science and Society”, organized by the Ministry of University and Research in collaboration with the National Institute for Nuclear Physics (INFN) under the Italian G7 Presidency, and held in Sardinia from October 28th to 30th in Su Gologone (Nuoro). The rich three-day program featured four thematic sessions, dedicated to exploring the key role of large research infrastructures in generating knowledge and value for society, promoting the sharing of ideas and best practices among policymakers, researchers, and socio-economic stakeholders. The opening remarks were delivered by the Minister of University and Research, Anna Maria Bernini, and the President of the Autonomous Region of Sardinia, Alessandra Todde. Among the nationally and internationally prominent speakers was also the President of Area Science Park, Caterina Petrillo, who contributed to the roundtable The Socio-Economic Benefits of Large Research Infrastructures. Here, speakers discussed the role of large infrastructures: not only centers for scientific knowledge production and high-quality FAIR data, but also true catalysts of innovative processes, which include training new generations of scientists, transferring technology to industry, and fostering regional development. During her speech, the President highlighted the importance of integrating these infrastructures into innovative ecosystems, scientific, and technological hubs, both public and private, where collaboration and shared projects can thrive. The objective of the G7 Conference on Large Research Infrastructures: Synergies and Impact on Science and Society is to stimulate dialogue to facilitate collaboration among the G7 countries, in order to optimize resources and maximize the complementarity of these large infrastructures, aiming toward a future of shared and sustainable innovation.  

The Data Engineering Laboratory (LADE) at Area Science Park has recently published an article in Nature – Scientific Data on protein sequence annotation. Thanks to technological advances in genomic sequencing, the number of known protein sequences has grown exponentially. Many of these sequences come from metagenomic projects that analyze environmental and clinical samples. Among the most relevant datasets in this field stands the Unified Human Gastrointestinal Proteome (UHGP) catalog, with a variety of applications in medicine and biology. However, the limited annotation of these sequences reduces their effectiveness. To address this issue, the DPCfam-UHGP dataset was developed, classifying UHGP sequences into protein families that typically group proteins sharing the same biological function. The dataset contains 10,778 families, generated through DPCfam clustering, an unsupervised method that organizes sequences into single- or multi-domain architectures. This project, part of Federico Barone‘s doctoral research supervised by Alessio Ansuini and Alberto Cazzaniga, exemplifies the fruitful interaction between data management and data science. In this context, the construction of a curated database of gastrointestinal proteins enabled more refined cataloging through advanced machine learning algorithms, allowing continuous database updates in fruitful feedback loop aimed at promoting new discoveries. The DPCfam-UHGP50 dataset, accessible through a web server, was developed following the best FAIR (Findable, Accessible, Interoperable, Reusable) practices, with the aim of fostering new discoveries in the field of human gastrointestinal tract metagenomics. Previously, LADE had already produced the DPCfam-UR50 database, accompanied by a publication in PLOS – Computational Biology.

Elettra Sincrotrone Trieste has announced the launch of ElettraBot, an innovative digital assistant based on artificial intelligence, designed to support researchers using the beamlines and laboratories of Elettra and FERMI. The first prototype has been successfully implemented for the TwinMic beamline, named TwinBot. This beamline, one of the 28 beamlines at the Italian synchrotron located in Trieste, specializes in X-ray microscopy, offering sub-micrometric spatial resolution. Thanks to its ability to combine transmission imaging and X-ray spectroscopy, TwinMic enables multidisciplinary studies ranging from biology to materials science. Its main applications include studying nanoparticle accumulation in cells and understanding chemical mechanisms related to asbestos in human tissues. TwinBot represents a significant innovation in basic research, providing immediate and intuitive access to the technical and experimental information offered by the TwinMic beamline. Leveraging artificial intelligence, TwinBot provides real-time responses to inquiries made in natural language, facilitating the preparation of proposals and experiments. TwinBot provides quick and accurate answers, significantly enhancing their operational efficiency, therefore researchers no longer need to spend long hours manually searching through technical documents. This tool has the potential to be extended to other beamlines and services at Elettra, further strengthening the scientific ecosystem of the institution. No other synchrotron has yet adopted similar technology for these purposes, making TwinBot a unique innovation. The project not only positions Elettra at the forefront of integrating artificial intelligence into scientific infrastructures but also establishes new standards for supporting basic research. Artificial intelligence is not limited to automating repetitive tasks, it goes far beyond that: it analyzes large volumes of data, identifies complex patterns, and can contribute to generating new insights that lead to innovative hypotheses, often based on extensive datasets or complex models that are difficult to analyze manually. This radically changes research methods, allowing scientists to focus more on creative and analytical aspects. Thus, artificial intelligence is rapidly becoming an essential element of modern scientific research, with applications that extend well beyond automation.

The goal of the “Phenotypic Fingerprinting School,” inaugurated on October 14 at Area Science Park, is to explore the complex metabolic pathways involved in cellular responses to infections and drugs through the use of complementary and integrable approaches and techniques. Organized in collaboration with Elettra Sincrotrone Trieste, ICGEB and CNR-IOM, the school is part of the “Pathogen Readiness Platform for CERIC-ERIC Upgrade” (PRP@CERIC) project. This project aims to develop a highly specialized research infrastructure, unique in Europe, integrating tools and expertise in biology, biochemistry, physics, bio-electronics, virology, genomics, bioinformatics, and data science to study human, animal and plant pathogens and respond quickly to new potential outbreaks. For four weeks, participants will engage in both theoretical and practical sessions, studying host-pathogen interactions from a multidisciplinary perspective. The program includes contributions from researchers of different PRP@CERIC partner institutions, as well as open lectures by internationally renowned experts, including Professor Piero Carninci, who will hold a seminar titled “My Travel from Genomic Technologies to Biology” on October 17 at Area Science Park. The project “Pathogen Readiness Platform for CERIC-ERIC Upgrade”– PRP@CERIC is funded by the National Recovery and Resilience Plan (PNRR) under Mission 4 “Education and Research,” Component 2 “From Research to Entreprise,” Investment Line 3.1 “Fund for the Creation of an Integrated System of Research and Innovation Infrastructures,” funded by the European Union – Next Generation EU.