InterLynk, a new platform for multi-tissue regeneration

The InterLynk project, funded by the EU and lasting four years, achieved significant milestones in regenerative medicine by developing an integrated platform for the repair of complex tissues, such as the temporomandibular joint (TMJ). The platform combines advanced biomaterials, computational modelling, and an innovative 3D bioprinting system to create customised scaffolds capable of supporting the regeneration of both hard and soft tissues within a single structure.

The project’s main innovations include:

• New Biomaterials: development of hydrogels and bone inks based on human-derived platelet lysates, rich in growth factors and protected by a patent, which serve as building blocks for the scaffolds
• Manufacturing Technology: a 3D printing system featuring a new “Print and Cure” printhead and an integrated electrospinning module, enabling real-time material solidification and adding ultrafine fibres to mimic the texture of natural tissues
• Clinical Approach: the work involved co-creation with surgeons and nearly 200 patients to ensure that the solutions aligned with clinical needs, aiming to bridge the gap in regenerative options that combine hard and soft tissues.

Impact and Future Perspectives

InterLynk demonstrates the feasibility of more integrated repair strategies for complex defects, offering the potential for future alternatives to prosthetics, especially in cases such as severe damage to the temporomandibular joint. The work lays the foundations for personalised and clinically relevant solutions with potential applications across a wide range of musculoskeletal defects.

Promoscience’s Contribution

Among the eight European partners in the project, Promoscience played an important role in enhancing and disseminating the project’s scientific results, drawing on its long-standing experience in communication and digital innovation. As part of the scientific communication activities, it also organised workshops at the International School Trieste to introduce middle-school students to biotechnology and to the outcomes of the InterLynk project.