DPCfam: unsupervised protein family classification by Density Peak Clustering of large sequence datasets

Abstract:

As the UniProt database approaches the 200 million entries’ mark, the vast majority of proteins it contains lack any experimental validation of their functions. In this context, the identification of homologous relationships between proteins remains the single most widely applicable tool for generating functional and structural hypotheses in silico. Although many databases exist that classify proteins and protein domains into homologous families, large sections of the sequence space remain unassigned.

Authors

Elena Tea Russo, Federico Barone, Alex Bateman, Stefano Cozzini, Marco Punta, Alessandro Laio

Journal

PLOS Computational Biology

Publication date

19/10/2022

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