Nanofabrication: an essential tool for modern bio-science

Cryo-microscopy techniques are emerging as fundamental components for the future of scientific research.

Despite significant technological advancements on the instrumental front, numerous aspects in sample preparation methodologies still require refinement and standardization.

While progress has been made across all levels, from instrumentation to sample preparation, challenges persist, demanding continued attention.

The introduction of a nanofabrication approach for producing substrates used in biological applications of cryo-microscopy is crucial for enhancing the reproducibility and statistical validity of conducted analyses.

Nanofabrication can address existing gaps in this field, significantly contributing to the enhancement of sample preparation protocols. This technology plays a key role in streamlining workflows and optimizing the precision of procedures.

Furthermore, nanofabrication extends to the production of devices used in conjunction with cryo-microscopy. These devices, such as detectors and sensors, are essential for detecting and quantifying bacterial contaminations from samples of different types and for various applications.

At IOM, two primary technologies are emerging in this context, focusing on approaches based on the use of MEMS (Micro-Electro-Mechanical Systems) and purely optical readouts to improve the effectiveness of conducted analyses.

In summary, the application of nanofabrication not only addresses gaps in sample preparation protocols but also plays a crucial role in the development of advanced technologies for the detection and characterization of biological samples using cryo-microscopy.

Speaker: Simone Dal Zilio, CNR – IOM