An integrative structural biophysics approach to study the interactions between ATP and neurotrophins

The seminar presents the application of an integrative structural biology approach to the field of neurotrophins.

The interaction of ATP with both mature NGF and its precursor was investigated with solution NMR and a set of complementary biophysical and computational methodologies.

The used methods are briefly presented, as well as the scientific results.

From these data, it was possible to identify the role of ATP in modulating the neurotrophin biology and this can explain some features of neurodegeneration.

Speaker: Francesca Paoletti, Institute of Crystallography – CNR